The cloister was completed in 1557, and features four groups of arches from the transition period from Gothic to Renaissance. In this space, next to the arcade on the east side, there are two chapels built by Bishop D. Manuel de Noronha, in the 16th century, one invoking S. Nicolau and the other Santo António. These chapels have well carved altars and the side walls of the S. Nicolau chapel are covered with magnificent ceramic panels (18th century) referring to S. Nicolau. Both have admirable wrought iron gates, from the best Portuguese metalwork.

The Lamego Cathedral, built from successive stages, is one of the most emblematic historical monuments in the entire Douro region. It was founded in 1129. It is a cathedral of Roman origin which, on the initial route, received Gothic additions, others already Manueline, maintaining the original Romanesque square tower although it was transferred from the side where in the century. The Cloister was built in the 16th century, but the rest of the architecture reflects the changes made in the 16th and 18th centuries, to the body of the church and chancel, including a Renaissance cloister with a dozen well proportioned arches.