The Church of Santiago de Mondrões was built in the first decades of the 16th century (Reign of D. Manuel I), when it benefited from the Manueline charter of the neighboring municipality of Penaguião. It is a temple dedicated to Santiago, with a single nave, with proportions width x height x depth typical of Manueline temples. Its Baroque exterior, the result of a 1744 reconstruction, hides a Manueline interior, with a nave with four uneven sections, marked by framed Tuscan pilasters, covered by starred vaults based on gummed corbels and decorated with different motifs.

In 1721 it belonged to the patronage of the religious of São Jerónimo do Mosteiro de Belém, which presents it with the title of guardian, and is attached to the Matrix of the Savior of Torgueda; he had a Brotherhood of Souls and four Confraternities, that of Nossa Senhora do Rosário, that of the Holy Name of Jesus, that of São Sebastião and that of Santiago, with the respective altars manufactured from what was necessary through alms.